In the world of longevity supplements, the idea of an “all-in-one” capsule might sound appealing. Why not take just one pill and get everything you need? However, the science tells a different story—one that highlights the importance of precision, bioavailability, and nutrient synergy.

At Vitruvin, we take a different approach. Instead of cramming multiple ingredients into a single capsule, we carefully formulate individual longevity supplements for maximum effectiveness. We then combine them into targeted bundles designed to support specific health goals, making it easier to achieve better results while using them. Here’s why this is a smarter choice for longevity and optimal health.

Different compounds of longevity supplements require specific dosages for optimal efficacy. When multiple active ingredients are squeezed into a single capsule, the dosage of each may become suboptimal, limiting the benefits.

Scientific Evidence:

• NAD+ Precursors (NMN & NMNH): Research shows that NMN and NMNH require specific dosages to effectively elevate NAD+ levels and support cellular energy production (Yoshino et al., 2021). Combining them with unrelated compounds in one capsule could result in ineffective dosing.

• Spermidine: Studies indicate that higher doses of spermidine are required to trigger autophagy and cellular renewal (Madeo et al., 2018). A diluted form in a multi-supplement capsule would not deliver the full effect.

By keeping ingredients separate, we ensure that each supplement provides the correct, research-backed dose—nothing more, nothing less.

Some compounds of longevity supplements when taken together, can reduce each other’s effectiveness. These interactions can occur at the level of absorption, metabolism, or cellular uptake.

Key Examples:

• Curcumin and Spermidine: Research suggests that curcumin can inhibit enzymes involved in polyamine biosynthesis, potentially reducing spermidine levels in the body (Minois et al., 2014). This suggests that taking curcumin and spermidine together may lower spermidine bioavailability, which is why they should be supplemented separately.

• Trans-Resveratrol vs. NMN/NMNH Absorption: Trans-resveratrol is fat-soluble, meaning it requires a healthy fat source (e.g., olive oil or omega-3s) to optimize absorption (Smoliga et al., 2013). NMN and NMNH, on the other hand, are water-soluble and do not require fats for absorption. These compounds dissolve efficiently in water and are rapidly absorbed with or without food (Yoshino et al., 2021). Combining these ingredients in a single capsule ignores their distinct absorption mechanisms, potentially reducing their effectiveness.

By providing these nutrients in separate longevity supplements, we allow you to optimize your intake—ensuring that each ingredient works at its full potential, free from interference by competing compounds.

Apigenin

• In the morning, apigenin functions as a potent anti-inflammatory, supporting cellular resilience and longevity (Shukla & Gupta, 2010). At night, apigenin acts as a GABA modulator, promoting deep sleep and recovery (Viola et al., 1995).

Berberine

• This powerful AMPK activator is best taken before meals to optimize glucose metabolism and insulin sensitivity (Turner et al., 2020).

A one-size-fits-all capsule cannot provide this level of customization—but our individual supplements allow you to tailor your regimen to your personal longevity goals.

Different compounds of longevity supplements require different environments to be absorbed properly.

• Trans-Resveratrol → Needs dietary fats for optimal absorption.
• NMN & NMNH → Water-soluble and absorbed on an empty stomach or with water.
• Curcumin → Requires piperine or a fat source to enhance bioavailability (Hewlings & Kalman, 2017).

A single capsule containing all of these ingredients would not optimize their absorption, leading to reduced effectiveness. Instead, separating them ensures your body gets the full benefit of each.

Multi-ingredient formulations often contain:

• Binders (to hold ingredients together)
• Fillers (to compensate for low doses)
• Chemical stabilizers (to prevent ingredient interactions)
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These additives can reduce absorption and introduce unnecessary synthetic compounds into your body.

At Vitruvin, we skip the fillers—delivering pure, potent supplements free from compromise.

Longevity is not a one-size-fits-all journey. Your longevity supplements should be as individualized as your health needs.

Why Personalization Matters

• Some people need higher doses of NMN based on age and lifestyle.
• Some individuals prefer taking spermidine with food to enhance digestion.
• Not everyone needs the same amount of trans-resveratrol based on dietary intake.
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With Vitruvin, you have the flexibility to take exactly what your body needs—nothing more, nothing less.

While an “all-in-one” supplement might seem convenient, it often comes at the cost of effectiveness. Scientific evidence overwhelmingly supports a targeted, precision-based approach to supplementation.

At Vitruvin, we ensure optimal dosing of our longevity supplements, so each ingredient delivers its full benefit. By formulating individual supplements, we avoid negative interactions, preventing ingredient competition that can reduce effectiveness. Our approach also improves bioavailability, carefully separating water-soluble and fat-soluble nutrients to maximize absorption. We use no fillers, binders, or stabilizers, offering only pure, research-backed longevity compounds. With tailored supplementation, our products are designed to align with your unique health goals. At Vitruvin, we prioritize science over convenience—because longevity is a journey that demands precision. Experience the difference for yourself and explore our longevity supplement bundles today.

1. Yoshino J, Baur JA, Imai S. (2021). NAD+ Intermediates and Metabolism in Aging and Disease. Annual Review of Medicine, 72, 217-236.https://pubmed.ncbi.nlm.nih.gov/29249689/
2. Smoliga JM, Baur JA, Hausenblas HA. (2013). Resveratrol and Health. Molecules, 18(9), 11045-11070.https://pubmed.ncbi.nlm.nih.gov/21688389/
3. Mori K, Obara Y, Moriya T, et al. (2009). Neuroprotective Effects of Hericium erinaceus. Biological & Pharmaceutical Bulletin, 32(5), 912-917.https://pubmed.ncbi.nlm.nih.gov/19336931/
4. Madeo F, Eisenberg T, Pietrocola F, Kroemer G. (2018). Spermidine in Health and Disease. Science, 359(6374), eaan2788.
5. Hewlings SJ, Kalman DS. (2017). Curcumin: A Review of Its Effects on Human Health. Foods, 6(10), 92.
6. Turner N, Li JY, Gosby A, et al. (2020). Berberine and Metabolic Regulation. Nature Communications, 11(1), 4058.